SR9009 comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Last reviewed on 2026-06-06. Where a claim depends on a specific study, the study is described rather than over-claimed.
SR9009 is frequently discussed alongside other REV-ERB ligands, including synthetic agonists and natural heme-related molecules. Its selectivity for REV-ERB over related nuclear receptors has been measured in binding and reporter assays, though off-target activity at higher concentrations is possible. The compound is prohibited in sport by the World Anti-Doping Agency, and it is not approved for any medical use in major jurisdictions. Products sold online may be labeled as research chemicals, and their identity and purity are not guaranteed by regulatory review.
SR9009 is a synthetic small molecule that acts on the nuclear receptors REV-ERBα and REV-ERBβ. These receptors are part of the circadian clock machinery and normally repress transcription of certain target genes. In laboratory research, SR9009 is used as a chemical tool to study how REV-ERB activity influences metabolism, inflammation, and daily biological rhythms. The compound is not an approved medicine, and its effects in humans remain largely uncharacterized. It is often described as an investigational agent rather than a therapeutic product.
SR9009 binds REV-ERB receptors and alters their repressive activity on target genes. This action can change transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. In rodent studies, treated animals have shown changes in muscle oxidative capacity and exercise performance, though effects vary by dose, duration, and model. The precise molecular steps connecting receptor binding to whole-body outcomes are still an active area of investigation. Findings in animals do not automatically translate to humans.
Because REV-ERB receptors are core clock components, SR9009 has been examined for effects on daily rhythms as well as metabolism. Research has explored whether the compound can shift or reinforce circadian gene expression in tissues such as liver and muscle. Some studies report improved metabolic markers in obese or diabetic mice, while others show context-dependent responses. Questions remain about which effects are direct, which are secondary to timing, and how they might differ across species.
SR9009 is a synthetic small molecule studied as an agonist of REV-ERB nuclear receptors. REV-ERB alpha and REV-ERB beta help regulate circadian rhythms and metabolic gene expression. In laboratory research, SR9009 has been used to probe how these receptors affect skeletal muscle, liver, and adipose tissue. The compound was identified in academic drug-discovery work and is often described in scientific literature by its chemical name and research code. It is not an approved medicine, and human clinical data remain limited or absent.
| Property | Value | Notes |
|---|---|---|
| Common name | SR9009 | Also marketed informally as Stenabolic |
| Chemical class | Synthetic REV-ERB agonist | Binds REV-ERBα and REV-ERBβ |
| Molecular formula | C24H30ClN3O4S | Approximate molecular weight 492 g/mol |
| CAS Registry Number | 1379686-30-2 | Identifier for the parent compound |
| Regulatory status | Not approved for human use | Prohibited in sport by WADA |
Regulatory treatment of SR9009 varies by country and region. It is not approved as a pharmaceutical, and several jurisdictions restrict its sale for human consumption. Some authorities classify it as a research chemical, a prescription-only substance, or a prohibited performance-enhancing agent in sport. Purchasers may encounter certificates of analysis, but these documents do not guarantee identity, purity, or legality. In research settings, institutional safety reviews and controlled procurement help ensure that materials are handled under appropriate oversight. The absence of harmonized rules means that legal status can change and requires verification.
Analytical identification of SR9009 typically relies on liquid chromatography coupled with tandem mass spectrometry. In biological samples, researchers first separate the compound from matrix components using protein precipitation, liquid-liquid extraction, or solid-phase extraction. High-performance liquid chromatography with ultraviolet detection and nuclear magnetic resonance spectroscopy can support structural confirmation of reference materials. Because SR9009 is a small, relatively lipophilic molecule, reverse-phase columns and acidic mobile phases are common. Laboratories often include isotope-labeled internal standards to improve quantification and to correct for ion suppression.
Regulatory and sporting contexts treat SR9009 as a prohibited substance in many elite competitions. Its presence on banned lists reflects concerns about performance enhancement and unknown long-term safety. Analytical chemists have developed methods to detect the parent compound and its metabolites in urine and blood. Literature discussions distinguish between in vitro potency, animal pharmacology, and anecdotal human reports. The latter are difficult to verify because products sold online may lack purity or contain different compounds.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. These receptors help regulate circadian rhythms, lipid metabolism, and inflammatory gene expression. In cell and animal experiments, SR9009 alters transcription of clock-controlled genes and metabolic pathways. The compound is not a hormone and does not resemble classical steroid structures. Its activity depends on binding to the ligand-binding domain of REV-ERB, where it can modify corepressor recruitment.
Several misconceptions surround SR9009. It is often described as a SARM, a steroid, or an exercise pill, but its known target is the REV-ERB receptor family. Rodent studies have examined exercise capacity and metabolic markers, yet human outcomes remain unproven. Oral bioavailability appears low in animals, and human pharmacokinetics are not well characterized. Online products may contain impurities or different compounds, so identity and purity testing are important for research use.
Analytical chemists detect SR9009 with liquid chromatography-tandem mass spectrometry, commonly abbreviated LC-MS/MS. Sample preparation may involve protein precipitation, liquid-liquid extraction, or solid-phase extraction before analysis. Laboratories can target the parent compound or its metabolites, depending on the matrix and the purpose of testing. Anti-doping methods require sensitive and specific assays because concentrations in biological samples can be low. Reference standards and validated methods are essential for reliable identification and quantification.
Regulatory agencies have not approved SR9009 for human therapeutic use. It is typically sold as a research chemical with labels stating that it is not for human consumption. The World Anti-Doping Agency prohibits the substance in sport, generally under the category of non-approved substances. Customs and national laws may restrict importation, sale, or possession. Product quality and legal status can vary by country and vendor, and therapeutic claims are not permitted in regulated advertising because the compound lacks approval.
These drugs are non-selective serotonin receptor agonists like serotonin and are serotonergic psychedelics due to activation of the serotonin 5-HT2A receptor. α-Methylserotonin is well-studied in preclinical research, but is not known to have been tested in humans.
=== Further uses and logistics integration === In the United States, drive-up banks often used pneumatic tubes to transport cash and documents between cars and tellers; by the 2020s some of these have been removed, obviated by the rise of mobile banking apps and the increasing sophistication of ATMs. Many hospitals have a computer-controlled pneumatic tube system to deliver drugs, documents, and specimens to and from laboratories and nurses' stations. Many factories use them to deliver parts quickly across large campuses. Many larger stores use systems to securely transport excess cash from checkout stands to back offices, and to send change back to cashiers. They are used in casinos to move money, chips, and cards quickly and securely. Japanese love hotels use them to allow customers to settle bills anonymously. NASA's original Mission Control Center had pneumatic tubes connecting controller consoles with staff support rooms. Mission Operations Control Room 2 was last used in its original configuration in 1992 and then remodeled for other missions. Because the room was designated a National Historic Landmark in 1985, it was decided in 2017 to restore it to its 1960s condition. The pneumatic tubes were removed and sent to the Cosmosphere in Kansas for restoration.
=== Techniques === There are four major methods used to quantify the metabolome of single cells; they are: fluorescence–based detection, fluorescence biosensors, FRET biosensors, and mass spectroscopy. The first three methods listed use fluorescence microscopy to detect molecules in a cell. Usually these assays use small fluorescent tags attached to molecules of interest, however this has been shown be too invasive for single cell metabolomics, and alters the activity of the metabolites. The current solution to this problem is to use fluorescent proteins which will act as metabolite detectors, fluorescing whenever they bind to a metabolite of interest. Mass spectroscopy is becoming the most frequently used method for single cell metabolomics. Its advantages are that there is no need to develop fluorescent proteins for all molecules of interest, and is capable of detecting metabolites in the femtomole range. Similar to the methods discussed in proteomics, there has also been success in combining mass spectroscopy with separation techniques such as capillary electrophoresis to quantify metabolites. This method is also capable of detecting metabolites present in femtomole concentrations. Another method utilizing capillary microsampling combined with mass spectrometry with ion mobility separation has been demonstrated to enhance the molecular coverage and ion separation for single cell metabolomics. Furthermore, direct infusion mass spectrometry, so call-ed live-single cell mass spectrometry, has also been successfully performed on human cells.
==== Effects ==== RO5263397 has been found to increase the firing rates of ventral tegmental area (VTA) dopaminergic neurons and dorsal raphe nucleus (DRN) serotonergic neurons in mouse brain slices ex vivo. This is in contrast to the high-efficacy TAAR1 agonists p-tyramine, RO5166017, and RO5256390, which inhibit these neurons in such systems, but is similar to the increased firing rates with the TAAR1 antagonist EPPTB, supporting a partially agonistic profile of RO5263397 at the mTAAR1. RO5263397 can partially and dose-dependently reverse the suppressive effects of RO5256390 on monoaminergic neuron firing in brain slices ex vivo. In contrast to VTA dopaminergic and DRN serotonergic neurons, RO5263397 had no effect on locus coeruleus (LC) noradrenergic neurons in the system, where the TAAR1 is notably not expressed. The effects of RO5263397 on the firing frequencies of monoaminergic neurons are absent in TAAR1 knockout mice. RO5263397 has been found to fully prevent methamphetamine-induced dopamine release in rat nucleus accumbens core (NAcc) brain slices ex vivo. Conversely, RO5263397 by itself had no effect on dopamine overflow in rat NAcc slices ex vivo. RO5263397 alone has no effect on locomotor activity in rodents in vivo. Similarly, RO5263397 did not affect locomotor activity in monkeys. Conversely, RO5263397 has been found to dose-dependently and fully inhibit cocaine-induced hyperlocomotion in mice in vivo. Likewise, it dose-dependently inhibited hyperlocomotion induced by the NMDA receptor antagonists phencyclidine (PCP) and L-687,414 in mice in vivo.
Sources: en.wikipedia.org
The persistence of American unipolar predominance in the international system since the end of the Cold War has caused a rupture in the American school of Realist … theory ... Yet the ongoing failure of potential rivals to the US, such as China, Russia, or the EU to develop military capabilities that come anywhere close to those of the US seems to have defied this prediction. Despite the apparently radical imbalance of the international political system, smaller states are not trying to build up their military power to match that of the US or forming formal alliance systems to oppose it… The absence of balancing against the US constitutes a serious anomaly for neorealist theory. Fareed Zakaria asks, "Why is no one ganging up against the United States?" And John Ikenberry and John M. Owen ask the same question. Prominent Historian of the Cold War, John Lewis Gaddis, poses a more general question and replies: Do the weak always unite against the strong? "In theory, yes, but in practice and in history, not necessarily." One of the issues the discipline of political science "has been wrestling with recently is why there is still no anti-American coalition despite the overwhelming dominance of the United States since the end of the Cold War." French or Chinese officials publicly denounce "hyperpower" and aspire for "multipolarity" but refrain from forming a counterbalancing coalition. "Rhetorically, leaders and public want the United States to be balanced" but "we find very little balancing." French academic Michel Winock said: "Before we could say we were on American side.
==== Naked mRNA injection ==== Naked mRNA injection means that the delivery of the vaccine is only done in a buffer solution. This mode of mRNA uptake has been known since the 1990s. The first worldwide clinical studies used intradermal injections of naked mRNA for vaccination. A variety of methods have been used to deliver naked mRNA, such as subcutaneous, intravenous, and intratumoral injections. Although naked mRNA delivery causes an immune response, the effect is relatively weak, and after injection the mRNA is often rapidly degraded.
Care of diabetes, obesity and other chronic diseases necessitates understanding the patient at the personal and social level as well as the molecular, and the physician–patient relationship can be an important therapeutic process. Apart from treating patients, many endocrinologists are involved in clinical science and medical research, teaching, and hospital management.
The Sphinx is said to have guarded the entrance to the Greek city of Thebes, asking a riddle to travellers to allow them passage. The exact riddle asked by the Sphinx was not specified by early tellers of the myth, and was not standardized as the one given below until late in Greek history. It was said in late lore that Hera or Ares sent the Sphinx from her Aethiopian homeland (the Greeks always remembered the foreign origin of the Sphinx) to Thebes in Greece where she asked all passersby the most famous riddle in history: "Which creature has one voice and yet becomes four-footed and two-footed and three-footed?" She strangled and devoured anyone who could not answer. Oedipus solved the riddle by answering: "Man—who crawls on all fours as a baby, then walks on two feet as an adult, and then uses a walking stick in old age". In some lesser accounts, there was a second riddle: "There are two sisters: one gives birth to the other and she, in turn, gives birth to the first. Who are the two sisters?" The answer is "day and night" (both words—ἡμέρα and νύξ, respectively—are feminine in Ancient Greek). This second riddle is also found in a Gascon version of the myth and could be very ancient. Bested at last, the Sphinx then threw herself from her high rock and died; or, in some versions Oedipus killed her. An alternative version tells that she devoured herself.
=== Cell turnover === Fat cells in some mice have been shown to drop in count due to fasting and other properties were observed when exposed to cold. If the adipocytes in the body reach their maximum capacity of fat, they may replicate to allow additional fat storage.
Sources: en.wikipedia.org
Aerobic conditioning Neurobiological effects of physical exercise - improves: Executive function Memory Stress management Physical fitness, including improving and maintaining these aspects of it: Accuracy Agility Balance Coordination Endurance Flexibility Power Speed Stamina Strength Prevention – exercise helps prevent: Cancer Drug addiction Hypertension Major depressive disorder Neurodegenerative disorders Obesity Osteoporosis Type 2 Diabetes
Taliban officials had not commented on the reports of airstrikes on military sites in Kandahar province. Pakistani troops attacked and destroyed Taliban border checkpoints in Zabul Province inflicting losses. Taliban authorities claimed that Pakistani conducted mortar strikes into Samkani district in Paktia province and artillery into Kunar with 82 shells hitting Sarkano District, 15 striking Dangam District and four in Shultan District. The Taliban claimed that one child was wounded and several residential properties were damaged, elsewhere, skirmishes in Kamdesh district of Nuristan killed two civilians, a mortar strike in Khost wounded a child and a civilian was killed and another wounded in skirmishes in Shkin District of Paktika Province. A policeman was killed in a militant sniper attack in Bajaur. A cylinder bomb attack on Miranshah camp killed two government officials. The Norwegian Refugee Council reported that a Pakistani artillery attack on an earthquake-affected refugee camp in Khas Kunar District, Kunar province, resulted in three people being killed and seven others being injured, while forcing 650 families from the camp to flee to safety. An Afghan media outlet reported that the Taliban were forcibly recruiting and deploying fighters, including civilians, from northern and northeastern Afghanistan to front lines along the Pakistan border, sometimes using financial incentives. It said that many were sent without their families' consent, causing concern among residents.
== Personal life == Vaghela was born to Laxmansinh and Nathuba on 21 July 1940 in Vasan in Gandhinagar district, in Gujarat. He completed Master of Arts in economics from Gujarat University. Vaghela married Gulab Ba on 9 June 1960, with whom he has three sons. His son Mahendrasinh was MLA from Bayad from 2012 to 2017.
== Agents == Currently, there are 10 ACE inhibitors approved for use in the United States by the FDA: captopril (1981), enalapril (1985), lisinopril (1987), benazepril (1991), fosinopril (1991), quinapril (1991), ramipril (1991), perindopril (1993), moexipril (1995) and trandolapril (1996). ACE inhibitors are easily identifiable by their common suffix, '-pril'. ACE inhibitors can be divided into three groups based on their molecular structure of the enzyme binding sites (sulfhydryl, phosphinyl, carboxyl) to the active center of ACE:
There are many variants in the size and shape of the thyroid gland, and in the position of the embedded parathyroid glands. Sometimes there is a third lobe present called the pyramidal lobe. When present, this lobe often stretches up to the hyoid bone from the thyroid isthmus and may be one to several divided lobes. The presence of this lobe ranges in reported studies from 18.3% to 44.6%. It was shown to more often arise from the left side and occasionally separated. The pyramidal lobe is also known as Lalouette's pyramid. The pyramidal lobe is a remnant of the thyroglossal duct, which usually wastes away during the thyroid gland's descent. Small accessory thyroid glands may in fact occur anywhere along the thyroglossal duct, from the foramen cecum of the tongue to the position of the thyroid in the adult. A small horn at the back of the thyroid lobes, usually close to the recurrent laryngeal nerve and the inferior thyroid artery, is called Zuckerkandl's tubercle. Other variants include a levator muscle of thyroid gland, connecting the isthmus to the body of the hyoid bone, and the presence of the small thyroid ima artery.
Sources: en.wikipedia.org
SR9009 is a synthetic research compound that binds and modulates the nuclear receptors REV-ERBα and REV-ERBβ. It is used in laboratory studies of circadian biology and metabolism, not as an approved medicine. It is also known by the informal name Stenabolic.
No. SR9009 has not been approved as a therapeutic drug in the United States, European Union, or other major markets. Human safety and efficacy data are very limited. Its presence in consumer products does not imply regulatory approval.
The World Anti-Doping Agency lists SR9009 as a prohibited substance because it can alter gene expression and metabolic pathways relevant to performance. The ban applies at all times, not only during competition. Detection relies on laboratory methods such as mass spectrometry.
SR9009 is a synthetic research compound that acts on REV-ERB nuclear receptors. It is not approved for human use and is sold only as a research chemical. Its effects have been studied mainly in cells and rodents.