The short version of research chemical fits in a sentence. The long version — which is the one that helps — is below.
Reviewed 2025-10-23. Anything still debated is marked as such rather than presented as settled.
Storage recommendations for SR9009 reference material typically specify a freezer at -20 °C or lower, with protection from moisture and light. Repeated freeze-thaw cycles can degrade small molecules and introduce variability. Stock solutions in dimethyl sulfoxide are often aliquoted to avoid repeated handling. Stability studies may examine degradation under heat, humidity, and light exposure. The compound's thiophene and nitro groups can participate in reactions that alter analytical signals over time, so such changes affect quantitative results.
Quality control for research materials includes identity confirmation by nuclear magnetic resonance and purity assessment by high-performance liquid chromatography. Mass spectrometry provides molecular weight confirmation and can detect related impurities. Purchasers should request a certificate of analysis that lists lot-specific data. Online products advertised for human use often lack such documentation. Distinguishing legitimate research material from mislabeled or contaminated samples is a recurring challenge in independent testing, and independent laboratories may use orthogonal methods to verify identity.
Most published work on SR9009 consists of preclinical studies. It is widely sold as a research chemical, a category that does not imply safety, efficacy, or pharmaceutical-grade quality. Sports anti-doping organizations have listed SR9009 as a prohibited substance, and its presence in an athlete sample can lead to sanctions. Legal status differs by country; in several jurisdictions it is not approved for human consumption and may be treated as an unapproved new drug.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not a steroid, peptide, or natural hormone. In scientific literature, it appears under the code SR9009 and in non-scientific contexts as Stenabolic. The compound was identified through chemical screening efforts aimed at targeting circadian clock components. Its status remains investigational, and no regulatory agency has approved it as a human medicine.
REV-ERB proteins help regulate daily cycles in gene expression, including genes tied to lipid and glucose metabolism. SR9009 binds these receptors and alters their activity in cell and animal experiments. Consequences observed in rodents include changes in skeletal muscle oxidative capacity, blood lipid levels, and exercise performance. The precise chain from receptor occupancy to whole-body effects is still an active area of study. Human responses cannot be assumed from rodent data.
| Property | Value | Notes |
|---|---|---|
| Typical storage temperature | -20 °C or lower | Desiccated and protected from light |
| Common analytical method | LC-MS/MS | Detects parent drug and metabolites |
| Solubility class | Lipophilic; soluble in organic solvents | Low aqueous solubility |
| Molecular weight | 437.94 g/mol | Calculated from reported formula |
| Synonyms | SR9009; REV-ERB agonist | Code name used in scientific literature |
Identity and purity of SR9009 samples are usually checked with chromatographic and spectrometric methods. High-performance liquid chromatography can separate the compound from related impurities, while mass spectrometry provides molecular mass confirmation. Nuclear magnetic resonance spectroscopy may be used for structural verification in research settings. No single method proves biological activity, and certificates of analysis should be reviewed alongside raw data. Independent testing is often needed because online products vary widely.
SR9009 stability depends on temperature, moisture, light, and solvent. Solid material is generally kept cool and dry, while solutions may require protection from repeated warming and cooling. Degradation can appear as color changes, precipitate, or new chromatographic peaks. Researchers should follow supplier instructions and their own stability data. Long-term storage conditions for human use have not been established because the compound lacks approved clinical formulation.
Identity and purity testing for SR9009 commonly uses liquid chromatography coupled with tandem mass spectrometry. This method separates the compound from matrix components and detects it by mass-to-charge transitions, providing sensitive and specific confirmation. Nuclear magnetic resonance spectroscopy can support structural identification, while high-performance liquid chromatography with ultraviolet detection may estimate purity. Because online products labeled as SR9009 may contain other substances or no active compound at all, independent verification is important in research settings. Certificates of analysis are useful but not a substitute for in-house testing.
Laboratory samples of SR9009 are typically supplied as a white to off-white powder. The compound dissolves readily in organic solvents such as dimethyl sulfoxide and ethanol, while its solubility in water is low. Because of this solubility profile, researchers often prepare concentrated stock solutions in an organic solvent before diluting them into aqueous assay buffers. Light exposure, moisture, and repeated freeze-thaw cycles can degrade many small molecules, so handling procedures usually aim to minimize these factors. Purity is commonly checked before use.
Acetylcholinesterase inhibitors: Acetylcholinesterase inhibitors prevent the degradation of acetylcholine, subsequently increasing its concentration and duration of action in the neuromuscular junction. Acetylcholinesterase inhibitors are primarily used to treat symptoms of dementia, Alzheimer's disease, Parkinson's disease, and myasthenia gravis. Butyrylcholinesterase inhibitors: Butyrylcholinesterease inhibitors prevent the degradation of butyrylcholine, which increases its concentration and duration of action in the neuromuscular junction. Like acetylcholinesterase inhibitors, butyrylcholinesterase inhibitors are regarded as a therapeutic option for Alzheimer's disease. Aminoglycosides: Aminoglycosides are frequently used in combinational antibacterial therapies for nosocomial respiratory tract infections, complicated intra-abdominal infections, sepsis, osteomyelitis caused by aerobic gram-negative bacilli, and complicated urinary tract infections. Seven neuromuscular drugs are approved by the US Food and Drug Administration, these drugs include: streptomycin, plazomicin, neomycin, amikacin, tobramycin, gentamicin, and paromomycin. It is clinically proven that aminoglycosides can exert neuromuscular blocking side effects. As aminoglycosides only have neuromuscular blocking side effects, they are not a major class of neuromuscular drugs.
President Biden signs his first executive orders reversing several Trump administration actions, including rejoining the Paris Agreement and the World Health Organization, repealing the 2017 travel bans, ending funding for the Mexico–United States border wall, and revoking the permit for the Keystone XL pipeline. January 21 – The Food and Drug Administration (FDA) approves Cabenuva as a complete regimen for the treatment of HIV/AIDS. January 22 – Recreational cannabis sales begin in Arizona. January 24 COVID-19 pandemic: Nationwide confirmed COVID-19 cases surpass 25 million. The Tampa Bay Buccaneers advance to Super Bowl LV after a 31–26 victory against the Green Bay Packers, the first time an NFL team will play the Super Bowl on their home field. January 25 President Biden repeals the Trump administration's ban on transgender personnel in the military. COVID-19 pandemic: Minnesota reports the first national case of the Lineage P.1 variant of SARS-CoV-2. Dominion Voting Systems sues former New York City mayor Rudy Giuliani, accusing him of defamation during the 2020 presidential election. January 26 COVID-19 pandemic: The Biden administration announces it will purchase 200 million COVID-19 vaccine doses from Pfizer/BioNTech and Moderna, in addition to the prior order of 400 million. January 27 The U.S. Army announces new personal grooming and appearance standards, relaxing rules regarding makeup and jewelry and allowing for more diverse hairstyles.
=== 1970s === 1970: Australian geologist and palaeontologist Dorothy Hill became the first female president of the Australian Academy of Science. 1970: New Zealand geologist and palynologist Rosemary Askin the first New Zealand woman to undertake her own research programme in Antarctica. 1970: Spanish biochemist Margarita Salas discovered and characterized the Φ29 phage DNA polymerase. She was also the first scientific woman elected to the Royal Spanish Academy and was the first woman recipient of the Carlos J. Finlay Prize for Microbiology. 1970: Samira Islam became the first Saudi Arabian person to earn a PhD in pharmacology. 1970: American astronomer Vera Rubin published the first evidence for dark matter. 1970: Polish geologist Franciszka Szymakowska became widely known because of her unique and detailed geological drawings that are still used today. 1971: Romanian chemist Ecaterina Ciorănescu-Nenițescu became a member of the New York Chemical Society. She was noted for developing synthesis processes for antituberculosis drugs and insecticides and creating new substances using cytostatic grafting. 1973: American physicist Anna Coble became the first African-American woman to receive a PhD in biophysics, completing her dissertation at University of Illinois. 1974: Dominican marine biologist Idelisa Bonnelly founded the Dominican Republic Academy of Science. 1975: Indian chemist Asima Chatterjee was elected the General President of the Indian Science Congress Association. She simultaneously became the first female scientist ever elected a member of the congress.
Initially, damage to the brain is regionally specific with the dorsal striatum in the subcortical basal ganglia being primarily affected, followed later by cortical involvement in all areas. Other areas of the basal ganglia affected include the substantia nigra; cortical involvement includes cortical layers 3, 5, and 6; also evident is involvement of the hippocampus, Purkinje cells in the cerebellum, lateral tuberal nuclei of the hypothalamus and parts of the thalamus. These areas are affected according to their structure and the types of neurons they contain, reducing in size as they lose cells. Striatal medium spiny neurons are the most vulnerable, particularly ones with projections towards the external globus pallidus, with interneurons and spiny cells projecting to the internal globus pallidus being less affected. HD also causes an abnormal increase in astrocytes and activation of the brain's immune cells, microglia. The basal ganglia play a key role in movement and behavior control. Their functions are not fully understood, but theories propose that they are part of the cognitive executive system and the motor circuit. The basal ganglia ordinarily inhibit a large number of circuits that generate specific movements. To initiate a particular movement, the cerebral cortex sends a signal to the basal ganglia that causes the inhibition to be released.
=== Academic career === Bumpus became a Professor of Medicine in the clinical pharmacology division of Johns Hopkins University School of Medicine, with a secondary appointment in the Department of Pharmacology and Molecular Sciences. She started her own laboratory at Johns Hopkins School of Medicine in 2010 as an Assistant Professor of Medicine and Pharmacology, was promoted to Associate Professor in February 2015, and received Professorship in 2020. Bumpus is known for her research on the metabolism of antiviral drugs used to treat HIV-1 and how genetic variations in drug-processing enzymes may impact these drugs' efficacy. She became Hopkins’ inaugural associate dean of institutional and student equity in 2015 and instituted mentoring programs to expand access to resources and opportunities. After holding that role for two years, in July 2017 she transitioned into a role as senior consulting strategist for Academic and Research Diversity, working with the chief diversity officer to develop and implement diversity and inclusion programs across Johns Hopkins School of Medicine. Bumpus received a Presidential Early Career Award for Scientists and Engineers in 2016. In July 2018, she was named as Associate Dean for Basic Research at Johns Hopkins University School of Medicine.
Sources: en.wikipedia.org
== Mechanism of action == Icotrokinra is a targeted oral peptide that selectively binds to and blocks the interleukin 23 receptor (IL-23R), thereby inhibiting IL-23-mediated signaling. The drug demonstrates high affinity for the human IL-23 receptor with a dissociation constant (KD) of 7.1 pM and inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM. The IL-23 pathway plays a central role in the inflammatory cascade underlying various autoimmune conditions, particularly those involving Th17 cells. Unlike injectable biologics that target IL-23 or its receptor, icotrokinra offers the convenience of oral administration while maintaining selective receptor binding.
Villino Cibrario in Via Saccarelli is another significant building designed by Barnaba Panizza in 1842. The building was equipped with a large garden which was eliminated to host the street. The neighbourhood has a high concentration of historic buildings in Art Nouveau style designed by architect Pietro Fenoglio (among the others, the prestigious Villino Raby in Corso Francia 8). Other significant buildings are the Villa Boringhieri in Via San Donato, and other Art Nouveau and Neo-Gothic buildings are situated in Via Piffetti and Via Durandi. Among the modern buildings of the district, the most significant one is, of course, the Torre BBPR Tower (which took the name from the architecture office who designed it). The building is representing the post-rationalism Italian architecture (same style of the better known Torre Velasca tower in the city of Milan). The tower is facing the central Piazza Statuto square. The district is crossed by some significant avenues: on Corso Svizzera, which crosses the district from north to south, faces the Business Centre Piero Della Francesca, where the offices of Tuttosport, one of the three national sports daily newspapers has its head offices. Also on Corso Svizzera, stands one of the oldest hospitals of the city, the Ospedale Amedeo di Savoia, specialised in infectious diseases. Other major avenues are Corso Umbria and Corso Tassoni. Another big avenue, which borders the district on its East, is Corso Principe Oddone, which in the past was along the railway to Milan.
=== NCBI identifiers === The NCBI defined a standard for the unique identifier used for the sequence (SeqID) in the header line. This allows a sequence that was obtained from a database to be labelled with a reference to its database record. The database identifier format is understood by the NCBI tools like makeblastdb and table2asn. The following list describes the NCBI FASTA defined format for sequence identifiers.
=== Configuration and wing === All-metal low-wing land monoplane with four wing-mounted low-bypass turbofan engines. Cantilever three-spar structure of modified trapezoid planform. Centre section integral with fuselage. Inboard sections, outboard sections and detachable leading and trailing edges. High-lift devices comprise full-span six-segment leading edge slats (contiguous at engine pylons) at up to 17.5% of chord (drooping to 35°), two-segment fixed-vane double-slotted trailing edge flaps occupying some 75% of the span (deploying to 40°) and five-segment spoilers (outboards used as spoilerons at high speeds, inboards used as lift dumpers on the ground). Two-segment outboard ailerons for low speed roll control. Boundary layer fences over pylons. Engines suspended from the wing on pylons act as anti-flutter weights. Trim range is 16–33% of mean aerodynamic chord.
Sources: en.wikipedia.org
Liquid chromatography-tandem mass spectrometry is a common approach. It can detect the parent compound and its metabolites in biological matrices.
Research samples are typically kept frozen, desiccated, and protected from light. Stock solutions are often aliquoted to reduce freeze-thaw cycles.
High-performance liquid chromatography and nuclear magnetic resonance are standard for purity and identity. Mass spectrometry confirms molecular weight.
It is a synthetic compound studied as an agonist of REV-ERB nuclear receptors. It is not an approved medicine and has mainly been examined in laboratory and animal research.